Cobalt-Catalyzed C(sp3)-H Functionalization Reactions

C-H functionalization reactions hold great potential for the streamlined synthesis of complex molecules and are currently a hot topic in organic synthesis. Among the various transition metals that have been used, cobalt has recently attracted increased attention as a catalyst for C-H functionalization reactions, owing to its ready availability and high reactivity. Although a number of cobalt-catalyzed C(sp(2))-H functionalization reactions have been reported to date, C(sp(3))-H functionalization reactions remain challenging. This Focus Review summarizes recent progress in cobalt-catalyzed C(sp(3))-H functionalization reactions that involve C-H activation to form organometallic intermediates.