期刊
CANCER MICROENVIRONMENT
卷 5, 期 1, 页码 29-38出版社
SPRINGER
DOI: 10.1007/s12307-011-0076-5
关键词
Force; Contractility; MRTF; Morphogenesis
类别
资金
- National Institutes of Health [GM083997, CA128660]
- David & Lucile Packard Foundation
- Alfred P. Sloan Foundation
- Susan G. Komen for the Cure
- Burroughs Wellcome Fund
- New Jersey Commission on Cancer Research
Epithelial-mesenchymal transition (EMT) is a phenotypic shift wherein epithelial cells lose or loosen attachments to their neighbors and assume a mesenchymallike morphology. EMT drives a variety of developmental processes, but may also be adopted by tumor cells during neoplastic progression. EMT is regulated by both biochemical and physical signals from the microenvironment, including mechanical stress, which is increasingly recognized to play a major role in development and disease progression. Biological systems generate, transmit and concentrate mechanical stress into spatial patterns; these gradients in mechanical stress may serve to spatially pattern developmental and pathologic EMTs. Here we review how epithelial tissues generate and respond to mechanical stress gradients, and highlight the mechanisms by which mechanical stress regulates and patterns EMT.
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