期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 4, 页码 253-268出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3175
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资金
- NCI NIH HHS [R01 CA100062, R01 CA141438, R01 CA084488] Funding Source: Medline
Myeloid cells are the most abundant nucleated haematopoietic cells in the human body and are a collection of distinct cell populations with many diverse functions. The three groups of terminally differentiated myeloid cells-macrophages, dendritic cells and granulocytes-are essential for the normal function of both the innate and adaptive immune systems. Mounting evidence indicates that the tumour microenvironment alters myeloid cells and can convert them into potent immunosuppressive cells. Here, we consider myeloid cells as an intricately connected, complex, single system and we focus on how tumours manipulate the myeloid system to evade the host immune response.
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