期刊
BIORESEARCH OPEN ACCESS
卷 1, 期 2, 页码 63-68出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/biores.2012.9902
关键词
immunodeficient swine; large-animal cancer model; melanoma; pancreatic carcinoma; xenografts
资金
- Kansas Agricultural Experiment Station
- Johnson Cancer Center
Animal models for cancer therapy are invaluable for preclinical testing of potential cancer treatments; however, therapies tested in such models often fail to translate into clinical settings. Therefore, a better preclinical model for cancer treatment testing is needed. Here we demonstrate that an immunodeficient line of pigs can host and support the growth of xenografted human tumors and has the potential to be an effective animal model for cancer therapy. Wild-type and immunodeficient pigs were injected subcutaneously in the left ear with human melanoma cells (A375SM cells) and in the right ear with human pancreatic carcinoma cells (PANC-1). All immunodeficient pigs developed tumors that were verified by histology and immunohistochemistry. Nonaffected littermates did not develop tumors. Immunodeficient pigs, which do not reject xenografted human tumors, have the potential to become an extremely useful animal model for cancer therapy because of their similarity in size, anatomy, and physiology to humans.
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