期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 6, 期 3, 页码 3862-3869出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.7b04192
关键词
Biomimetic mineralization; Hydroxyapatite nanowhiskers; Graphene oxide; Poly(lactic acid) nanocomposites; Osteoblastic proliferation
资金
- National Natural Science Foundation of China [51673131]
- Seedling Project of Scientific and Technological Innovation of Sichuan Province [2016079]
- State Key Laboratory of Medicinal Chemical Biology
Central to the design and development of biomedical-adaptive graphene oxide (GO) is functional modification of GO amenable to technologically reliable and economically viable processing. Here we describe a high efficiency and low-temperature approach to in situ synthesis of hydroxyapatite (HA) nanowhiskers at GO surfaces (HA@GO), strategically involving microwave-assisted mineralization in stimulated body fluid at room temperature. Being preferentially nucleated and accommodated at GO surfaces, the highly crystalline HA nanowhiskers with an average diameter of 20 nm and a length of 150 nm were characterized by coherent bonding with the host nanosheets. The strong GO HA interactions, combined with the high density of oxygen functional groups, endowed the HA@GO with good exfoliation and dispersion in a poly(lactic acid) (PLA) matrix even at the highest filler content of 30 wt % (HG30). Inheriting the excellent biocompatibility of HA and the remarkable strength of GO, the PLA/HA@GO nanocomposites exhibited an unusual combination of prominent cytocompatibility with osteoblast cells and high mechanical strength and toughness. In particular, compared to that of the normal PLA/HA counterpart, HG30 exhibited a >85% increase in cell viability, accompanied by 2- and 7.9-fold increases in tensile strength and toughness (105 MPa and 2.9 MJ/m(3)), respectively. This work paves a facile yet effective way to GO functionalization with biologically beneficial HA nanowhiskers, which may prompt the realistic development of GO-based biomaterials, especially in the realm of polymer/GO nanocomposites.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据