期刊
POLYMERS
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/polym10040415
关键词
sulfated xylorhamnoglycuronan; electrocompaction; biomimicry; tissue regeneration; skin scaffold; fibroblasts
资金
- Australian Research Council (ARC) Centre of Excellence Scheme [CE140100012]
- Australian National Fabrication Facility (ANFF)-Materials Node
- Bauer grant
- ARC Industrial Transformation Training Centre in Additive Biomanufacturing [ARC IC160100026]
Skin autografts are in great demand due to injuries and disease, but there are challenges using live tissue sources, and synthetic tissue is still in its infancy. In this study, an electrocompaction method was applied to fabricate the densely packed and highly ordered collagen/sulfated xylorhamnoglycuronan (SXRGlu) scaffold which closely mimicked the major structure and components in natural skin tissue. The fabricated electrocompacted collagen/SXRGlu matrices (ECLCU) were characterized in terms of micromorphology, mechanical property, water uptake ability and degradability. The viability, proliferation and morphology of human dermal fibroblasts (HDFs) cells on the fabricated matrices were also evaluated. The results indicated that the electrocompaction process could promote HDFs proliferation and SXRGlu could improve the water uptake ability and matrices' stability against collagenase degradation, and support fibroblast spreading on the ECLCU matrices. Therefore, all these results suggest that the electrocompacted collagen/SXRGlu scaffold is a potential candidate as a dermal substitute with enhanced biostability and biocompatibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据