期刊
OPEN BIOLOGY
卷 8, 期 5, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rsob.180002
关键词
BCL-2 family; apoptosis; BAX/BAK
资金
- Cancer Research UK
- Breast Cancer Now
- Tenovus Scotland
The ability of a cell to undergo mitochondrial apoptosis is governed by pro-and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro-versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death during development and maintains organismal health. When unbalanced, the BCL-2 family can act as a barrier to apoptosis and facilitate tumour development and resistance to cancer therapy. Here we discuss the BCL-2 family, their deregulation in cancer and recent pharmaceutical developments to target specific members of this family as cancer therapy.
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