期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 4, 页码 282-294出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3190
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资金
- US National Institutes of Health [HD037091, HL075453, AI084457, AI071163]
- Cancer Research Institute
- Rheumatology T32 Postdoctoral Training Grant [5T32AR007108]
- German Research Foundation (Deutsche Forschungsgemeinschaft) [ME2709/2-1]
Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR) and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B cell responses, directly linking cell-intrinsic innate and adaptive immune programmes. Although most data regarding B cell-specific functions of the TLR signalling pathway have been obtained in mice, the discovery of patients with a deficiency in this pathway has recently provided an insight into human B cell responses. Here, we highlight the importance of the integration of signalling pathways downstream of BCRs and TLRs in modulating B cell function, focusing when possible on B cell-intrinsic roles.
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