4.7 Article

Identification of Intermediate in Evolutionary Model of Enterohemorrhagic Escherichia coli O157

期刊

EMERGING INFECTIOUS DISEASES
卷 18, 期 4, 页码 582-588

出版社

CENTERS DISEASE CONTROL
DOI: 10.3201/eid1804.111414

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资金

  1. German Federal Ministry of Education and Research [0315219A, 01K10801]
  2. EU Network ERA-NET PathoGenoMics II [0315443]
  3. medical faculty of the University Minister [BD9817044]

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Highly pathogenic enterohemorrhagic Escherichia coli (EHEC) O157 cause a spectrum of clinical signs that include diarrhea, bloody diarrhea, and hemolytic uremic syndrome. The current evolutionary model of EHEC O157:H7/H- consists of a stepwise evolution scenario proceeding from O55:H7 to a node (hypothetical intermediate) that then branches into sorbitol-fermenting (SF) O157:H- and non-SF (NSF) O157:H7. To identify this hypothetical intermediate, we performed single nucleotide polymorphism analysis by sequencing of 92 randomly distributed backbone genomic regions of 40 O157:H7/H- isolates. Overall, 111 single nucleotide polymorphisms were identified in 75/92 partial open reading frames after sequencing 51,041 nt/strain. The EHEC O157:H7 strain LSU-61 from deer occupied an intermediate position between O55:H7 and both O157 branches (SF and NSF O157), complementing the stepwise evolutionary model of EHEC O157:H7/H-. The animal origin of this intermediate emphasizes the value of nonhuman reservoirs in the clarification of the evolution of human pathogens.

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