期刊
JOURNAL OF GINSENG RESEARCH
卷 42, 期 1, 页码 98-106出版社
KOREAN SOC GINSENG
DOI: 10.1016/j.jgr.2017.09.001
关键词
network pharmacology; Panax ginseng; polypharmacology; traditional Asian medicine
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIP
- Ministry of Science, ICT & Futue Planning) [2017-0129]
- Korea Food Institute, Korea [E016450001]
Panax ginseng has been used since ancient times based on the traditional Asian medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies concerning P. ginseng have focused on specific mechanisms of action of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases. In order to decipher the systems-level mechanism of multiple ingredients of P. ginseng, a novel approach is needed beyond conventional reductive analysis. We aim to review the systems-level mechanism of P. ginseng by adopting novel analytical framework-network pharmacology. Here, we constructed a compound-target network of P. ginseng using experimentally validated and machine learning-based prediction results. The targets of the network were analyzed in terms of related biological process, pathways, and diseases. The majority of targets were found to be related with primary metabolic process, signal transduction, nitrogen compound metabolic process, blood circulation, immune system process, cell-cell signaling, biosynthetic process, and neurological system process. In pathway enrichment analysis of targets, mainly the terms related with neural activity showed significant enrichment and formed a cluster. Finally, relative degrees analysis for the target-disease association of P. ginseng revealed several categories of related diseases, including respiratory, psychiatric, and cardiovascular diseases. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
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