期刊
JOURNAL OF GINSENG RESEARCH
卷 42, 期 1, 页码 68-74出版社
KOREAN SOC GINSENG
DOI: 10.1016/j.jgr.2016.12.012
关键词
ginseng; ginsenoside Rg(3); inflammation; resolution
资金
- Korean National Research Foundation - Korean government (MSIP) [2009-0083538]
- Korea-Japan Basic Scientific Cooperation Program [NRF-2015K2A2A4000081]
Background: Ginsenosides have been reported to have many health benefits, including anti-inflammatory effects, and the resolution of inflammation is now considered to be an active process driven by M2-type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation. Methods: Mouse peritoneal macrophages were polarized into M1 or M2 phenotypes. Reverse transcription-polymerase chain reaction, Western blotting, and measurement of nitric oxide (NO) and prostaglandin E-2 levels were performed in vitro and in a zymosan-induced peritonitis C57BL/6 mouse model. Results: Ginsenoside Rg(3) was identified as a proresolving ginseng compound based on the induction of M2 macrophage polarization. Ginsenoside Rg(3) not only induced the expression of arginase-1 (a representative M2 marker gene), but also suppressed M1 marker genes, such as inducible NO synthase, and NO levels. The proresolving activity of ginsenoside Rg(3) was also observed in vivo in a zymosan-induced peritonitis model. Ginsenoside Rg(3) accelerated the resolution process when administered at peak inflammatory response into the peritoneal cavity. Conclusion: These results suggest that ginsenoside Rg(3) induces the M2 polarization of macrophages and accelerates the resolution of inflammation. This finding opens a new avenue in ginseng pharmacology. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
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