期刊
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY
卷 63, 期 1, 页码 3811-3818出版社
SOC CHILENA QUIMICA
DOI: 10.4067/s0717-97072018000103811
关键词
Phthalic acid; 3,4-Dihydropyrimidinone; Substituted dihydro-2-oxypyrrole; Biodegradable green catalyst; Multi-component reactions; Green chemistry
资金
- Research council of the University of Sistan and Baluchestan
Phthalic acid as a green, biodegradable economical and environmentally benign nature catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives via beta-keto esters, aldehyde derivatives and urea/thiourea under thermal and solvent-free conditions and one-pot four-component domino condensation of substituted dihydro-2-oxypyrrole by reaction of dialkyl acetylenedicarboxylate, formaldehyde and amines (aromatic and aliphatic) under ambient temperature with short reaction times and excellent yields is reported. The most benefits this procedure are such as green, biodegradable, inexpensive and non-toxic catalyst, eco-friendly, high catalytic activity, efficient, easily separation with no column chromatographic separation, simple operational procedures, one-pot. excellent yields, environmentally benign nature.
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