期刊
GOLD BULLETIN
卷 45, 期 1, 页码 23-34出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13404-011-0040-7
关键词
Gold(I) complexes; Sulfanylpropenoic acids; 2-Cyclopentylidene-2-sulfanylacetic acid; Antimicrobial studies
资金
- Direccion Xeral de I+D, Xunta de Galicia, Spain [IN845B-2010/121]
Reaction of NaAuCl4 center dot H2O and thiodiglycol (1:3 molar ratio) with 3-(aryl)-2-sulfanylpropenoic acids, H(2)xspa=[x:p=3-phenyl-, f=3-(2-furyl)-, t=3-(2-thienyl)-, o-py=3-(2-pyridyl)-, Clp=3-(2-chlorophenyl)-, -o-mp=3(2-methoxyphenyl)-, -p-mp=3-(4-methoxyphenyl)-, -o-hp=3-(2-hydroxyphenyl)-, -p-hp=3-(4-hydroxyphenyl)-, diBr-o-hp=3-(3,5-dibromo-2-hydroxyphenyl)] and 2-cyclopentylidene- 2-sulfanylacetic acid (H(2)cpa) in a 1:1 metal/ligand molar ratio gave compounds of the type [Au(Hxspa)] or [Au(Hcpa)]. These compounds were reacted with diisopropylamine to afford [HQ][Au(xspa)] or [HQ][Au(cpa)] (HQ=diisopropylammonium) and with NaOH to afford Na[Au(xspa)] center dot H2O and Na[Au(cpa)] center dot H2O. All of the new compounds were isolated and characterised by IR and H-1 and C-13 NMR spectroscopy. The antimicrobial activities of the complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Pseudomonas aeruginosa and carbapenem-resistant P. aeruginosa were evaluated and compared to those of the equivalent silver(I) complexes. The comparison shows that the gold compounds generally show better activity than the silver analogues against S. aureus and B. subtilis, but low sensitivity against E. coli, P. aeruginosa and C. albicans, suggesting a different mode of antimicrobial action for equivalent silver and gold compounds.
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