期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 5, 页码 325-338出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3198
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资金
- US National Institutes of Health [K01 AR053573, R01 NS064599]
- National Multiple Sclerosis Society [RG4180-A-1]
- Lupus Research Institute
- Cancer Research Institute
- American Lebanese Syrian Associated Charities
The evolutionarily conserved kinase mTOR (mammalian target of rapamycin) couples cell growth and metabolism to environmental inputs in eukaryotes. T cells depend on mTOR signalling to integrate immune signals and metabolic cues for their proper maintenance and activation. Under steady-state conditions, mTOR is actively controlled by multiple inhibitory mechanisms, and this enforces normal T cell homeostasis. Antigen recognition by naive CD4(+) and CD8(+) T cells triggers mTOR activation, which in turn programmes the differentiation of these cells into functionally distinct lineages. This Review focuses on the signalling mechanisms of mTOR in T cell homeostatic and functional fates, and discusses the therapeutic implications of targeting mTOR in T cells.
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