期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2018.00047
关键词
frontotemporal lobar degeneration; diffusion tensor imaging; fractional anisotropy; neuropathology; staging
资金
- BMBF (Federal Ministry of Education and Research, Germany) [FKZ O1GI1007A]
- Deutsche Forschungsgemeinschaft (German Research Foundation) [LU 336/15-1]
- National Health and Medical Research Council (NHMRC) [APP1037746]
- Australian Research Council (ARC) Centre of Excellence in Cognition and its Disorders Memory Node [CE11000102]
- Parkinson's Disease Foundation [PDF-IRG-1307]
- Michael Fox Foundation [MJFF-11362]
- National Health and Medical Research Council of Australia [APP1103258]
Objective: Recently, the characteristic longitudinal distribution pattern of the underlying phosphorylated TDP-43 (pTDP-43) pathology in the behavioral variant of frontotemporal dementia (bvFTD) excluding Pick's disease (PiD) across specific brain regions was described. The aim of the present study was to investigate whether in vivo investigations of bvFTD patients by use of diffusion tensor imaging (DTI) were consistent with these proposed patterns of progression. Methods: Sixty-two bvFTD patients and 47 controls underwent DTI in a multicenter study design. Of these, 49 bvFTD patients and 34 controls had a follow-up scan after similar to 12 months. Cross-sectional and longitudinal alterations were assessed by a two-fold analysis, i. e., voxelwise comparison of fractional anisotropy (FA) maps and a tract of interest-based (TOI) approach, which identifies tract structures that could be assigned to brain regions associated with disease progression. Results: Whole brain-based spatial statistics showed white matter alterations predominantly in the frontal lobes cross-sectionally and longitudinally. The TOIs of bvFTD neuroimaging stages 1 and 2 (uncinate fascicle-bvFTD pattern I; corticostriatal pathway-bvFTD pattern II) showed highly significant differences between bvFTD patients and controls. The corticospinal tract-associated TOI (bvFTD pattern III) did not differ between groups, whereas the differences in the optic radiation (bvFTD pattern IV) reached significance. The findings in the corticospinal tract were due to a dichotomous behavior of FA changes there. Conclusion: Longitudinal TOI analysis demonstrated a pattern of whitematter pathways alterations consistent with patterns of pTDP-43 pathology.
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