期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2018.00058
关键词
laterality; N-back; aging; fMRI; superior parietal
资金
- Northern Portugal Regional Operational Programme (NORTE), under the Portugal Partnership Agreement, through the European Regional Development Fund (FEDER)
- European Commission [HEALTH-F2-2010-259772]
- FEDER through the Competitiveness Factors Operational Programme (COMPETE)
- Foundation for Science and Technology (FCT) [POCI-01-0145-FEDER-007038]
- Fundacao Calouste Gulbenkian (Portugal) [P-139977]
- PANINI-Physical Activity and Nutrition Influences In Ageing'' (European Commission (Horizon)) [GA 675003]
- Fundacao para a Ciencia e a Tecnologia (FCT) via Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC) [SFRH/BD/52291/2013, PD/BD/106050/2015]
- Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BPD/80118/2011, SFRH/BD/90078/2012]
- FCT/MEC
- ON.2-ONOVONORTE-North Portugal Regional Operational Programme, of the National Strategic Reference Framework (NSRF), through FEDER [FCTANR/NEU-OSD/0258/2012]
- [NORTE-01-0145-FEDER-000013]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/80118/2011, PD/BD/106050/2015, SFRH/BD/90078/2012] Funding Source: FCT
Functional hemispheric asymmetries have been described in different cognitive processes, such as decision-making and motivation. Variations in the pattern of left/right activity have been associated with normal brain functioning, and with neuropsychiatric diseases. Such asymmetries in brain activity evolve throughout life and are thought to decrease with aging, but clear associations with cognitive function have never been established. Herein, we assessed functional laterality during a working memory task (N-Back) in a healthy aging cohort ( over 50 years old) and associated these asymmetries with performance in the test. Activity of lobule VI of the cerebellar hemisphere and angular gyrus was found to be lateralized to the right hemisphere, while the precentral gyrus presented left > right activation during this task. Interestingly, 1-Back accuracy was positively correlated with left > right superior parietal lobule activation, which was mostly due to the influence of the left hemisphere. In conclusion, although regions were mostly symmetrically activated during the N-Back task, performance in working memory in aged individuals seems to benefit from lateralized involvement of the superior parietal lobule.
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