期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 32, 期 -, 页码 97-106出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2018.03.005
关键词
Biospecimens; ABCD study; Substance use; Gonadal hormones; Genetics; Environmental exposures
资金
- NCATS NIH HHS [KL2 TR001444] Funding Source: Medline
- NIAAA NIH HHS [K01 AA026889] Funding Source: Medline
- NIDA NIH HHS [U01 DA041089, U24 DA041123, U01 DA041120, U01 DA041048] Funding Source: Medline
Biospecimen collection in the Adolescent Brain Cognitive Development (ABCD) study - of hair samples, shed deciduous (baby) teeth, and body fluids - will serve dual functions of screening for study eligibility, and providing measures of biological processes thought to predict or correlate with key study outcomes on brain and cognitive development. Biosamples are being collected annually to screen for recency of drug use prior to the neuroimaging or cognitive testing visit, and to store for the following future studies: (1) on the effects of exposure to illicit and recreational drugs (including alcohol and nicotine); (2) of pubertal hormones on brain and cognitive developmental trajectories; (3) on the contribution of genomics and epigenomics to child and adolescent development and behavioral outcomes; and (4) with pre- and post-natal exposure to environmental neurotoxicants and drugs of abuse measured from novel tooth analyses. The present manuscript describes the rationales for inclusion and selection of the specific biospecimens, methodological considerations for each measure, future plans for assessment of biospecimens during follow-up visits, and preliminary ABCD data to illustrate methodological considerations.
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