期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 31, 期 -, 页码 11-19出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2018.04.002
关键词
Dyslexia; Tractography; White matter pathway; Phonology; Morphology; Chinese
资金
- National Key Basic Research Program of China [2014CB846103]
- Key Project of Philosophical and Social Science Foundation, ministry of education [11JZD041]
- National Natural Science Foundation of China [31271082, 31500886, 31671126]
- Fundamental Research Funds for the Central Universities [2017XTCX04]
- Interdiscipline Research Funds of Beijing Normal University
- Agence Nationale de la Recherche [ANR-11-BSV4-014-01, ANR-10-LABX-0087 IEC, ANR-10-IDEX-0001-02 PSL*]
- China Scholarship Council
- China Postdoctoral Science Foundation [2016M591098]
- NSFC-CNRS Joint Research Project Grant [31611130107]
Chinese is a logographic language that is different from alphabetic languages in visual and semantic complexity. Thus far, it is still unclear whether Chinese children with dyslexia show similar disruption of white matter pathways as in alphabetic languages. The present study focused on the alteration of white matter pathways in Chinese children with dyslexia. Using diffusion tensor imaging tractography, the bilateral arcuate fasciculus (AF-anterior, AF-posterior and AF-direct segments), inferior fronto-occipital fasciculus (IFOF) and inferior longitudinal fasciculus (ILF) were delineated in each individual's native space. Compared with age-matched controls, Chinese children with dyslexia showed reduced fractional anisotropy in the left AF-direct and the left ILF. Further regression analyses revealed a functional dissociation between the left AF-direct and the left ILF. The AFdirect tract integrity was associated with phonological processing skill, an ability important for reading in all writing systems, while the ILF integrity was associated with morphological processing skill, an ability more strongly recruited for Chinese reading. In conclusion, the double disruption locus in Chinese children with dyslexia, and the functional dissociation between dorsal and ventral pathways reflect both universal and specific properties of reading in Chinese.
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