Antimicrobial efficacy of a novel povidone iodine contact lens disinfection system

Purpose: Contact lens (CL) wear is a risk factor for the acquisition of microbial keratitis. Accordingly, compliance to manufacturers' recommended hygiene and disinfection procedures are vital to safe (CL) use. In this study we evaluated a novel povidone-iodine (PI) (CL) disinfection system (cleadew, Ophtecs Corporation, Japan) against a range of bacterial, fungal and Acanthamoeba. Methods: Antimicrobial assays were conducted according to ISO 14729 using the recommended strains of bacteria and fungi, with and without the presence of organic soil. Regrowth of bacteria and fungi in the disinfection system was also examined. The activity on biofilms formed from Stenotrophomonas maltophilia and Achromobacter sp. was evaluated. Efficacy against A. castellanii trophozoites and cysts was also investigated. Results: The PI system gave > 4 log(10) kill of all bacteria and fungi following the manufacturer's recommended disinfection and cleaning time of 4 h, with or without the presence of organic soil. No regrowth of organisms was found after 14 days in the neutralized solution. In the biofilm studies the system resulted in at least a 7 log(10) reduction in viability of bacteria. For Acanthamoeba, > 3 log(10) kill of trophozoites and 1.1-2.8 log(10) kill for the cyst stage was obtained. Conclusions: The PI system effective against a variety of pathogenic microorganisms under a range of test conditions. Strict compliance to recommended CL hygiene procedures is essential for safe CL wear. The use of care systems such as PI, with broad spectrum antimicrobial activity, may aid in the prevention of potentially sight threatening microbial keratitis.