期刊
CHEMPLUSCHEM
卷 83, 期 5, 页码 339-347出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.201800035
关键词
antitumor agents; fluorescence; iridium; metallarectangles; self-assembly
资金
- Incheon National University, Incheon, Republic of Korea
- National Research Foundation of Korea - Ministry of Science, ICT & Future Planning [NRF-2016R1A2B4010376]
A new 4-ethynylpyridine 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based ligand L, which was synthesized by means of the Sonogashira coupling method, was used to obtain two new [2+2] iridium-based metallarectangles, 3 and 4. Ligand L and metallarectangles 3 and 4 were fully characterized through various analytical techniques. The structure of rectangle 4 was further confirmed by single-crystal X-ray diffraction analysis, which showed the formation of an expected [2+2] supramolecule, in which the iridium metal centers were bridged with ligand L to form the desired metallarectangle 4. In the context of the growing biological interest in metallarectangles, rectangle 4 was found to be highly active against two types of cancer cells, with IC50 values almost threefold superior to those of cisplatin. Both 3 and 4 showed dose-dependent abilities to bind bovine serum albumin and salmon sperm DNA; this indicated their tendency to interact with such bio-molecules as a potential mode of action.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据