期刊
CELL REPORTS
卷 22, 期 7, 页码 1710-1721出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.01.064
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资金
- ERC Starter Grant [282047]
- Wellcome Trust Investigator Award [095589/Z/11/Z]
- FP7 EC DESIRE grant
- Lister Institute prize
- BBSRC [BB/L022974/1]
- UK Medical Research Council (MRC)
- Francis Crick Institute (MRC)
- Francis Crick Institute (Cancer Research UK)
- Francis Crick Institute (Wellcome Trust)
- European Research Council (ERC) [282047] Funding Source: European Research Council (ERC)
- Biotechnology and Biological Sciences Research Council [BB/L022974/1] Funding Source: researchfish
- Medical Research Council [MR/N026063/1] Funding Source: researchfish
- The Francis Crick Institute [10002, 10128] Funding Source: researchfish
- BBSRC [BB/L022974/1] Funding Source: UKRI
- MRC [MR/N026063/1] Funding Source: UKRI
- Wellcome Trust [095589/Z/11/Z] Funding Source: Wellcome Trust
Cortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how the correct number of cortical interneurons (CIs) is established in the mammalian forebrain. CIs are generated in excess from basal forebrain progenitors, and their final numbers are adjusted via an intrinsically determined program of apoptosis that takes place during an early postnatal window. Here, we provide evidence that the extent of CI apoptosis during this critical period is plastic and cell-type specific and can be reduced in a cell-autonomous manner by acute increases in neuronal activity. We propose that the physiological state of the emerging neural network controls the activity levels of local CIs to modulate their numbers in a homeostatic manner.
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