期刊
CELL REPORTS
卷 22, 期 1, 页码 269-285出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.12.039
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资金
- Ellison Medical Foundation New Scholar in Aging Award
- Chapman Foundation
- NIH-NINDS [R01 NS089791]
- Hearst Foundation
- Pew Foundation
- Dana Foundation
- Whitehall Foundation
- NIH-NCI [CCSG P30 014195]
- Helmsley Trust
- NGS Core Facility of the Salk Institute
- Helmsley Charitable Trust
Aging brains undergo cognitive decline, associated with decreased neuronal synapse number and function and altered metabolism. Astrocytes regulate neuronal synapse formation and function in development and adulthood, but whether these properties change during aging, contributing to neuronal dysfunction, is unknown. We addressed this by generating aged and adult astrocyte transcriptomes from multiple mouse brain regions. These data provide a comprehensive RNA-seq database of adult and aged astrocyte gene expression, available online as a resource. We identify astrocyte genes altered by aging across brain regions and regionally unique aging changes. Aging astrocytes show minimal alteration of homeostatic and neurotransmission-regulating genes. However, aging astrocytes upregulate genes that eliminate synapses and partially resemble reactive astrocytes. We further identified heterogeneous expression of synapse-regulating genes between astrocytes from different cortical regions. We find that alterations to astrocytes in aging create an environment permissive to synapse elimination and neuronal damage, potentially contributing to aging-associated cognitive decline.
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