期刊
CELL REPORTS
卷 22, 期 13, 页码 3409-3415出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.03.016
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J014400/1, BB/L001896/1]
- Wellcome Trust [206401/Z/17/Z]
- BBSRC [BB/L001896/1, BB/L02134X/1] Funding Source: UKRI
- Wellcome Trust [206401/Z/17/Z] Funding Source: Wellcome Trust
Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may contribute to mnemonic processing are not known. We demonstrate that nAChRs in the prefrontal cortex exhibit subtype-specific roles in associative memory encoding and retrieval. We present evidence that these separate roles of nAChRs may rely on bidirectional modulation of plasticity at synaptic inputs to the prefrontal cortex that are essential for associative recognition memory.
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