期刊
BMJ OPEN
卷 8, 期 3, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/bmjopen-2017-019438
关键词
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资金
- Canadian Institutes of Health Research through the Canada-wide Human Nutrition Trialists' Network (NTN) [129920]
- Canada Foundation for Innovation (CFI)
- Ministry of Research and Innovation's Ontario Research Fund (ORF)
- Toronto 3D Postdoctoral Fellowship Award
- Government of Canada through the Canada Research Chair Endowment
- PSI Graham Farquharson Knowledge Translation Fellowship
- Canadian Diabetes Association (CDA) Clinician Scientist award
- CIHR INMD/CNS New Investigator Partnership Prize
- Banting and Best Diabetes Centre Sun Life Financial New Investigator Award
Objective Carbohydrate staples such as pasta have been implicated in the obesity epidemic. It is unclear whether pasta contributes to weight gain or like other low-glycaemic index (GI) foods contributes to weight loss. We synthesised the evidence of the effect of pasta on measures of adiposity. Design Systematic review and meta-analysis using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. Data sources MEDLINE, Embase, CINAHL and the Cochrane Library were searched through 7 February 2017. Eligibility criteria for selecting studies We included randomised controlled trials >= 3weeks assessing the effect of pasta alone or in the context of low-GI dietary patterns on measures of global (body weight, body mass index (BMI), body fat) and regional (waist circumference (WC), waist-to-hip ratio (WHR), sagittal abdominal diameter (SAD)) adiposity in adults. Data extraction and synthesis Two independent reviewers extracted data and assessed risk of bias. Data were pooled using the generic inverse-variance method and expressed as mean differences (MDs) with 95% Cls. Heterogeneity was assessed (Cochran Q statistic) and quantified (12 statistic). GRADE assessed the certainty of the evidence. Results We identified no trial comparisons of the effect of pasta alone and 32 trial comparisons n =2448 participants) of the effect of pasta in the context of low-GI dietary patterns. Pasta in the context of low-GI dietary patterns significantly reduced body weight (MD=-0.63 kg; 95% CI 0.84 to 0.42 kg) and BMI (MD=-0.26kg/m(2); 95% CI 0.36 to 0.16 kg/m(2)) compared with higher-GI dietary patterns. There was no effect on other measures of adiposity. The certainty of the evidence was graded as moderate for body weight, BMI, WHR and SAD and low for WC and body fat. Conclusions Pasta in the context of low-GI dietary patterns does not adversely affect adiposity and even reduces body weight and BMI compared with higher-GI dietary patterns. Future trials should assess the effect of pasta in the context of other 'healthy' dietary patterns.
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