期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201701357
关键词
immobilized enzymes; intraparticle FRET; photodynamic therapies; two-photon excitation; vaterite nanoparticles
资金
- National Nature Science Foundation of China [21673056, 21433010, 21320102004, 81402719, 21503236]
- National Basic Research Program of China [2013CB932800]
- Open Project of National & Local United Engineering Lab for Power Battery, Northeast Normal University [130017503]
Photodynamic therapy (PDT) still faces two main problems on cancer therapy. One is how to improve PDT efficiency against hypoxic environment of tumors. The other one is how to overcome the limit of short wavelength light to increase PDT treatment depth. In this work, an intraparticle fluorescence resonance energy transfer (FRET) platform is designed to address these problems together. The nanoparticles are doped with multicomponents, such as catalase, two-photon dyes, and traditional photosensitizers, with a simple one-pot and green method. On the one hand, catalase can catalyze intracellular H2O2 into O-2 and promote PDT efficiency. One the other hand, photosensitizers can be excited indirectly by two-photon lasers through an intraparticle FRET mechanism, which results in deeper tissue penetration for PDT. These properties are verified through the material induced cytotoxicity in light or in dark and in vivo blocking blood-vessel experiment.
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