期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 20, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201800484
关键词
biochips; cancer diagnostics; extracellular vesicles; isolation and detection; liquid biopsies
资金
- National Natural Science Foundation [21425314, 20141061]
- Beijing Municipal Science AMP
- Technology Commission [Z161100000116037]
- National Program for Support of Top-Notch Young Professionals
Extracellular vesicles (EVs) are emerging as one of the many new and promising biomarkers for liquid biopsy of cancer due to their loading capability of some specific proteins and nucleic acids that are closely associated with cancer states. As such, the isolation and detection of cancer-derived EVs offer important information in noninvasive diagnosis of early-stage cancer and real-time monitoring of cancer development. In light of the importance of EVs, over the last decade, researchers have made remarkable innovations to advance the development of EV isolation and detection methods by taking advantage of microfluidics, biomolecule probes, nanomaterials, surface plasmon, optics, and so on. This review introduces the basic properties of EVs and common cancer-derived EV ingredients, and provides a comprehensive overview of EV isolation and detection strategies, with emphasis on liquid biopsies of EVs for cancer diagnostics.
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