期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 16, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201800375
关键词
Au@PDA-I-125; embolization; intra-irradiation; radiosensitization; SPECT/CT
资金
- National Natural Science Foundation of China [81471714, 81701761]
- Scientific Research Foundation of Second Military Medical University of China [2012QN15]
Au nanoparticles (3.8 +/- 0.6 nm) are assembled to sub-micrometer Au particles (186.3 +/- 20.4 nm) and covered with adhesive polydopamine (PDA) as embolism beads (198.8 +/- 23.2 nm). Radioactive iodine-125 is labeled to Au@PDA to introduce the function of intra-irradiation. For the therapeutic effects of Au@PDA-I-125, Au particles sensitize the radiation to MHCC97H hepatoma cells and tumor-bearing mice. At the cellular level, after being treated with a relatively low-dose (5 Gy) -ray, Au-sensitized radiotherapy (RT) leads to an immediate increase of intracellular reactive oxygen species, accompanying with an increase of cell apoptosis. Due to the intra-irradiation, self-healing of RT-leaded DNA double-strand breakage is suppressed, inducing a further increase of cell apoptosis after RT treatment. Likewise, 3 cycles of sensitized RT leads to a valid control of tumor volume growth, but Au@PDA-I-125 has no harm or radioactive residual on or in the radiosensitive organs, including the thyroid, heart, lungs, liver, and spleen. Additionally, photons emitted from I-125 and high X-ray absorption of the Au element makes the beads suitable for single photon emission computed tomography/computed tomography (SPECT/CT) imaging. Therefore, as theranostic embolism beads, Au@PDA-I-125 can both enhance the therapeutic effects of external RT, and provide a real-time SPECT/CT monitoring of therapeutic time window.
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