期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 11, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201701347
关键词
3D bioprinting; alginate-based hydrogels; patient-specific bioinks; platelet-rich plasma (PRP); tissue engineering
资金
- National Institutes of Health [HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392, 5T32EB016652, 1T32EB016652]
- University of Nebraska-Lincoln
- Nebraska Tobacco Settlement Biomedical Research Enhancement Funds
- Al-Sagri Research Fund at Massachusetts General Hospital
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR073822, R01AR057837] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [T32EB016652] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM126831] Funding Source: NIH RePORTER
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs. PRP contains a cocktail of growth factors enhancing angiogenesis, stem cell recruitment, and tissue regeneration. Here, the development of an alginate-based bioink that can be printed and crosslinked upon implantation through exposure to native calcium ions is reported. This platform can be used for the controlled release of PRP-associated growth factors which may ultimately enhance vascularization and stem cell migration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据