期刊
ACS MACRO LETTERS
卷 7, 期 2, 页码 137-142出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00999
关键词
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资金
- National Science Foundation of China [81761148028, 81401458]
- Science and Technology Commission of Shanghai Municipality [17540712000, 15520711400]
- Fundamental Research Funds for the Central Universities
- FCT-Fundacao para a Ciencia e a Tecnologia (CQM, Portuguese Government funds) [PEst-OE/QUI/UI0674/2013]
- ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao through Centro de Quimica da Madeira-CQM+ (Madeira) [M1420-01-0145-FEDER-000005]
Development of sensitive contrast agents for positive magnetic resonance (MR) imaging of biosystems still remains a great challenge. Herein, we report a facile process to construct hybrid alginate (AG) nanogels (NGs) loaded with manganese oxide (Mn3O4) nanoparticles (NPs) for enhanced tumor MR imaging. The obtained AG/PEI-Mn3O4 NGs with a mean size of 141.6 nm display excellent colloidal stability in aqueous solution and good cytocornpatibility in the studied concentration range. Moreover, the hybrid NGs have a high r(1) relaxivity of 26.12 mM(-1) s(-1), which is about 19.5 times higher than that of PEI-Mn3O4 NPs with PEI surface amine acetylated (PEI.Ac-Mn3O4 NPs). Furthermore, the AG/PEI-Mn3O4 NGs presented longer blood circulation time and better tumor MR imaging performances in vivo than PEI.Ac-Mn3O4 NPs. With the good biosafety confirmed by histological examinations, the developed AG/PEI-Mn3O4 NGs may be potentially used as an efficient contrast agent for enhanced MR imaging of different biosystems.
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