期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 43, 页码 24023-24031出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b06896
关键词
hydrogel; self-healing; pH responsive; dynamic covalent chemistry; Diels-Alder click chemistry; tissue-adhesive
资金
- National Basic Research Program of China (973 Program) [2012CB619100]
- National Natural Science Foundation of China [51372085, 21404028]
- Guangdong-Hong Kong common technology bidding project [2013B010136003]
- Fundamental Research Funds for the Central Universities
- Science and Technology Program of Guangdong Province [2012A061100002]
Hydrogel, as a good cartilage tissue-engineered scaffold, not only has to possess robust mechanical property but also has to have an intrinsic self-healing property to integrate itself or the surrounding host cartilage. In this work a double cross-linked network (DN) was designed and prepared by combining Diels Alder click reaction and acylhydrazone bond. The DA reaction maintained the hydrogel's structural integrity and mechanical strength in physiological environment, while the dynamic covalent acylhydrazone bond resulted in hydrogel's self-healing property and controlled the on off switch of network cross-link density. At the same time, the aldehyde groups contained in hydrogel further promote good integration of the hydrogel to surrounding tissue based on aldehyde-amine Schiff-base reaction. This kind of hydrogel has good structural integrity, autonomous self-healing, and tissue-adhesive property and simultaneously will have a good application in tissue engineering and tissue repair field.
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