期刊
THERANOSTICS
卷 8, 期 6, 页码 1591-1606出版社
IVYSPRING INT PUBL
DOI: 10.7150/thno.22430
关键词
Melanin; Liposome; Photoacoustic imaging; MRI; Photothermal ablation; Nanomedicine
资金
- National Key R&D Program of China [2016YFA0203700]
- National Natural Science Foundation of China [81571688, 81771845, 81371718, 51722211, 51672303]
- Young Elite Scientist Sponsorship Program by CAST [2015QNRC001]
- Cutting-edge Research Projects [cstc2014jcyjA10013]
- Chongqing Foundation [cstc2014jcyjA10013]
Background: The construction of theranostic nanosystems with concurrently high biosafety and therapeutic performance is a challenge but has great significance for the clinical translation of nanomedicine for combating cancer. Methods: Bio-inspired melanin-based nanoliposomes (Lip-Mel) as theranostic agents were constructed for simultaneous photoacoustic (PA) imaging-and T-1-weighted magnetic resonance (MR) imaging-guided photothermal ablation of tumors, which was demonstrated both in vitro and in vivo. The high biosafety of Lip-Mel was also systematically evaluated. Results: The achieved Lip-Mel nanoliposomes demonstrated their imaging capability for both PA and T-1-weighted MR imaging (r(1) = 0.25 mM(-1)center dot s(-1)) both in vitro and in vivo, providing the potential for therapeutic guidance and monitoring. Importantly, the desirable photothermal-conversion efficiency of the as-prepared Lip-Mel achieved complete eradication of tumors in breast cancer-bearing mice, exhibiting remarkable photothermal-based therapeutic performance. In particular, the efficient encapsulation of melanin into the PEGylated liposome mitigated the potential toxicity of melanin and improved the photothermal performance of the loaded melanin. Systematic in vivo biosafety evaluations demonstrated the high biocompatibility of Lip-Mel at a high dose of 100 mg/ kg. Conclusion: In this work, we reported a bioinspired strategy where melanin, a natural product in the human body, is encapsulated into PEGylated nanoliposomes for efficient theranostics with high biocompatibility. This work provides a new strategy for creating desirable theranostic agents with concurrent high biocompatibility and satisfactory theranostic performance through the use of materials that totally originate from biosystems.
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