期刊
STEM CELL RESEARCH & THERAPY
卷 9, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s13287-017-0765-1
关键词
CXCR7; Cell migration; Homing; Hematopoiesis; Leukemia
资金
- Fundacao de Amparo Pesquisa a do Estado de Sao Paulo (FAPESP)
- CNPq
- CAPES
- INCT- Sangue
CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34(+) and U937 cell migration and prevents downregulation of CXCR4 by CXCL12 stimulation. In addition, CXCR7 contributes to homing of acute myeloid leukemia and normal progenitor cells to the bone marrow and spleen of NOD/SCID mice. In summary, this study shows an essential role of CXCR7, together with CXCR4, in the control of normal and malignant hematopoietic cell migration and homing induced by CXCL12.
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