期刊
SCIENTIFIC REPORTS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-22066-6
关键词
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资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2016R1A2B4007172]
- Pioneer Research Center Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2014M3C1A3001208]
- Global Research Laboratory (GRL) Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2013K1A1A2A02050616]
- Nuclear R&D program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2017M2A2A6A02018535]
- Royal Society Research Grant [RG160449]
- EPSRC Centre for Innovative Manufacturing in Large-Area Electronics Pathfinder Grant
- Lancaster University Faculty of Science and Technology Early Career Internal Grant
- National Research Foundation of Korea [2014M3C1A3001208, 2017M2A2A6A02018535, 2016R1A2B4007172, 2013K1A1A2A02050616] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Conductive polymers, including polypyrrole (PPy), have been extensively explored to fabricate electrically conductive biomaterials for bioelectrodes and tissue engineering scaffolds. For their in vivo uses, a sterilization method without severe impairment of original material properties and performance is necessary. Gamma-ray radiation has been commonly applied for sterilization of medical products because of its simple and uniform sterilization without heat generation. Herein we describe the first study on gamma-ray sterilization of PPy bioelectrodes and its effects on their characteristics. We irradiated PPy bioelectrodes with different doses (0-75 kGy) of gamma-rays. Gamma-ray irradiation of the PPy (gamma-PPy) increased the oxygenation and hydrophilicity of the surfaces. Interestingly, gamma-ray irradiation did not alter the electrical impedances and conductivities of the PPy substrates. Additionally, gamma-PPy prepared with various dopants (e.g., para-toluene sulfonate, polystyrene sulfonate, and chlorine) showed the electrochemical properties similar to the non-irradiated control. Gamma-ray irradiation at doses of >= 15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. gamma-PPy substrates also showed cytocompatibility similar to untreated control PPy, indicating no substantial alteration of cytocompatibility. In conclusion, gamma ray sterilization is a viable method of sterilization of conducting polymer-based biomaterials for biomedical applications.
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