期刊
INTERNATIONAL JOURNAL OF ORAL SCIENCE
卷 4, 期 2, 页码 64-68出版社
SICHUAN UNIV
DOI: 10.1038/ijos.2012.33
关键词
endochondral ossification; intramembranous ossification; osteogenesis; vascular endothelial growth factor
Osteogenesis and angiogenesis are two closely correlated processes during bone growth, development, remodelling and repair. Vascular endothelial growth factor (VEGF) is an essential mediator during the process of angiogenesis. Based on an extensive literature search, which was carried out using the PubMed database and the keywords of osteogenesis, VEGF, endochondral ossification and intramembranous ossification, this manuscript reviews the role of VEGF in ossification, with emphasis on its effect in endochondral and intramembranous ossification. Osteogenesis and angiogenesis are closely correlated processes. VEGF acts as an essential mediator during these processes. It not only functions in bone angiogenesis but also in various aspects of bone development. International Journal of Oral Science (2012) 4, 64-68; doi:10.1038/ijos.2012.33; published online 22 June 2012
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