期刊
SCIENTIFIC REPORTS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-18456-x
关键词
-
资金
- Ministry of Education, Culture, Sports, Science, and Technology
- Ministry of Health, Labour, and Welfare
- Kobayashi Cancer Research Foundation
- Princess Takamatsu Cancer Research Fund, Japan
- National Institute of Biomedical Innovation
- Osaka University Drug Discovery Funds
- Takeda Science and Medical Research Foundation
- Princess Takamatsu Cancer Research Fund
- Suzuken Memorial Foundation
- Pancreas Research Foundation of Japan
- Nakatomi Foundation
- Grants-in-Aid for Scientific Research [15H05664, 17K19698] Funding Source: KAKEN
The significance of mitochondrial metabolism in cancer cells has recently been gaining attention. Among other findings, One-carbon folate metabolism has been reported to be closely associated with cellular characteristics in cancer. To study molecular targets for efficient cancer therapy, we investigated the association between the expressions of genes that code enzymes involved in one-carbon metabolism and survival rate of patients with adenocarcinomas of the colorectum and lung. Patients with high expression of genes that control the metabolic cycle of tetrahydrofolate (THF) in mitochondria, SHMT2, MTHFD2, and ALDH1L2, have a shorter overall survival rate compared with patients with low expression of these genes. Our results revealed that these genes could be novel and more promising anticancer targets than dihydrofolate reductase (DHFR), the current target of drug therapy linked with folate metabolism, suggesting the rationale of drug discovery in cancer medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据