期刊
SCIENTIFIC REPORTS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-18652-9
关键词
-
资金
- Wellcome Trust [090532/Z/09/Z, 102811, 08957]
The transcriptional repressor Blimp-1 originally cloned as a silencer of type I interferon (IFN)-beta gene expression controls cell fate decisions in multiple tissue contexts. Conditional inactivation in the mammary gland was recently shown to disrupt epithelial cell architecture. Here we report that Blimp-1 regulates expression of viral defense, IFN signaling and MHC class I pathways, and directly targets the transcriptional activator Stat1. Blimp-1 functional loss in 3D cultures of mammary epithelial cells (MECs) results in accumulation of dsRNA and expression of type III IFN-lambda. Cultures treated with IFN lambda similarly display defective lumen formation. These results demonstrate that type III IFN-lambda profoundly influences the behavior of MECs and identify Blimp-1 as a critical regulator of IFN signaling cascades.
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