相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Neuronal human BACE1 knockin induces systemic diabetes in mice
Kaja Plucinska et al.
DIABETOLOGIA (2016)
Diet-Induced Obese Mice Retain Endogenous Leptin Action
Nickki Ottaway et al.
CELL METABOLISM (2015)
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation
Julia R. Clarke et al.
EMBO MOLECULAR MEDICINE (2015)
Leptin Mediates the Increase in Blood Pressure Associated with Obesity
Stephanie E. Simonds et al.
CELL (2014)
Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
D. Lee Hamilton et al.
DIABETOLOGIA (2014)
Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake
Kavon Rezai-Zadeh et al.
MOLECULAR METABOLISM (2014)
Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?
Joshua P. Thaler et al.
DIABETES (2013)
AZ-4217: A High Potency BACE Inhibitor Displaying Acute Central Efficacy in Different In Vivo Models and Reduced Amyloid Deposition in Tg2576 Mice
Susanna Eketjall et al.
JOURNAL OF NEUROSCIENCE (2013)
Leptin signaling and leptin resistance
Yingjiang Zhou et al.
FRONTIERS OF MEDICINE (2013)
Inflammatory cause of metabolic syndrome via brain stress and NF-κB
Dongsheng Cai et al.
AGING-US (2012)
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Paul J. Meakin et al.
BIOCHEMICAL JOURNAL (2012)
Amyloid-β Induces Hepatic Insulin Resistance by Activating JAK2/STAT3/SOCS-1 Signaling Pathway
Yi Zhang et al.
DIABETES (2012)
Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease
Linda Chami et al.
MOLECULAR NEURODEGENERATION (2012)
Diet-Induced Obesity Attenuates Fasting-Induced Hyperphagia
D. I. Briggs et al.
JOURNAL OF NEUROENDOCRINOLOGY (2011)
Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons
Linh Vong et al.
NEURON (2011)
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
Ya-Xiong Tao
ENDOCRINE REVIEWS (2010)
Obesity and leptin resistance: distinguishing cause from effect
Martin G. Myers et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)
Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
Wei-Qin Zhao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Lale Ozcan et al.
CELL METABOLISM (2009)
Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
Xiaoqing Zhang et al.
CELL (2008)
Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease
J. H. Stockley et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Endoplasmic Reticulum Stress Induces Leptin Resistance
Toru Hosoi et al.
MOLECULAR PHARMACOLOGY (2008)
β-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques:: Implications for Alzheimer's disease pathogenesis
Jie Zhao et al.
JOURNAL OF NEUROSCIENCE (2007)
Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons
Pablo J. Enriori et al.
CELL METABOLISM (2007)
Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle
Tonya L. Martin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Pathogenic mechanisms in Alzheimer's disease
Lucia Pastorino et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2006)
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
CT De Souza et al.
ENDOCRINOLOGY (2005)
Rapid rewiring of arcuate nucleus feeding circuits by leptin
S Pinto et al.
SCIENCE (2004)
Increased risk of type 2 diabetes in Alzheimer disease
J Janson et al.
DIABETES (2004)
Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
H Münzberg et al.
ENDOCRINOLOGY (2004)
Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression
J Wilsey et al.
JOURNAL OF ENDOCRINOLOGY (2004)
BACE1 (beta-secretase) transgenic neurochernical deficits ind knockout mice: identification of and behavioral changes
SM Harrison et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2003)
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
MA Cowley et al.
NATURE (2001)
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
C Bjorbæk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Leptin regulation of neuroendocrine systems
RS Ahima et al.
FRONTIERS IN NEUROENDOCRINOLOGY (2000)
Activation of downstream signals by the long form of the leptin receptor
AS Banks et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)