期刊
SCIENTIFIC REPORTS
卷 8, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-20185-8
关键词
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资金
- JSPS Postdoctoral Fellowship for Research Abroad
- Singapore Ministry of Health's National Medical Research Council under Zika Response Research Fund [NMRC/ZRRF/0002/2016]
- University of Texas Medical Branch (UTMB) startup award
- University of Texas STARs Award
- CDC grant [SCON2016-01353]
- UTMB CTSA [UL1TR-001439]
- Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation
Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with an increasing number of patients, various clinical features such as microcephaly, Guillain-Barre syndrome and thrombocytopenia have also been reported. To determine which host factors are related to pathogenesis, the E protein of ZIKV was analyzed with the Informational Spectrum Method, which identifies common information encoded by primary structures of the virus and the respective host protein. The data showed that the ZIKV E protein and the complement component C1q cross-spectra are characterized by a single dominant peak at the frequency F = 0.338, suggesting similar biological properties. Indeed, C1q-specific antibodies were detected in sera obtained from mice and monkeys infected with ZIKV. As C1q has been known to be involved not only in immunity, but also in synaptic organization and different autoimmune diseases, a ZIKV-induced anti-C1q antibody response may contribute to the neurological complications. These findings might also be exploited for the design of safe and efficacious vaccines in the future.
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