4.6 Article

Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study

期刊

RSC ADVANCES
卷 8, 期 8, 页码 4472-4477

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra13176c

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资金

  1. National Natural Science Foundation of China [21601142, 20902071]
  2. Wuhan Science and Technology Talent Training Program of Chenguang Project [2015070404010190]
  3. Key Project of Scientific Research Project of Hubei Provincial Department of Education [D20141506]
  4. Natural Science Foundation of Hubei Province [2017CFB689]
  5. Changshu HKBU Technology Company Limited

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A methylene violet 3RAX-conjugated porphyrin has been designed and synthesized as a potential photosensitizer in photodynamic therapy because of its high DNA binding constant and the efficacy in inhibiting cancer cells with subcellular localization.

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