期刊
RSC ADVANCES
卷 8, 期 14, 页码 7533-7549出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra13510f
关键词
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资金
- National Natural Science Foundation of China [81171681]
- Training Program of Outstanding Doctoral Student by Norman Bethune Health Science Center of Jilin University [YB201501]
- Scientific Development Program of Jilin Province [20160101109JC, 20150414006GH, 20150312028ZG, 20130206060GX]
- Graduate Innovation Fund of Jilin University [2017032]
- Medjaden Academy & Research Foundation for Young Scientists [MJR20170016]
Functional active wound dressings are expected to provide a moist wound environment, offer protection from secondary infections, remove wound exudate and accelerate tissue regeneration, as well as to improve the efficiency of wound healing. Chitosan-based hydrogels are considered as ideal materials for enhancing wound healing owing to their biodegradable, biocompatible, non-toxic, antimicrobial, biologically adhesive, biological activity and hemostatic effects. Chitosan-based hydrogels have been demonstrated to promote wound healing at different wound healing stages, and also can alleviate the factors against wound healing (such as excessive inflammatory and chronic wound infection). The unique biological properties of a chitosan-based hydrogel enable it to serve as both a wound dressing and as a drug delivery system (DDS) to deliver antibacterial agents, growth factors, stem cells and so on, which could further accelerate wound healing. For various kinds of wounds, chitosan-based hydrogels are able to promote the effectiveness of wound healing by modifying or combining with other polymers, and carrying different types of active substances. In this review, we will take a close look at the application of chitosan-based hydrogels in wound dressings and DDS to enhance wound healing.
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