期刊
JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE
卷 56, 期 3, 页码 334-340出版社
KOREAN CHEMICAL SOC
DOI: 10.5012/jkcs.2012.56.3.334
关键词
Biphenyl-3,5-dihydro-2H-thiazolopyrimidines derivatives; Antioxidant activity; Antibacterial; Antifungal activities
资金
- School of Chemistry, University of KwaZulu- Natal, Westville campus, Durban, South Africa
- Department of Chemistry, Sri Venkateswara University, Tirupati, India
A new series of ethyl 2-(4-substitutedbenzylidene)-5-(3'-(ethoxycarbonyl) biphenyl-4-yl)-7-methyl-3-oxo-3,5-dihydro- 2H-thiazolo[3,2-a] pyrimidine-6-carboxylate derivatives (8a-j) were synthesized. The newly synthesized compounds were characterized by IR, H-1 NMR, C-13 NMR, LCMS mass and C, H, N analyses. All newly synthesized compounds were screened for their In vitro antioxidant activity (Scavenging of hydrogen peroxide, Scavenging of nitric oxide radical, and Lipid peroxidation inhibitory activity), antibacterial (Escheria coli, Pseudonmonas aeruginosa (gram-negative bacteria), Bacillus subtillis, Staphylococcus aureus (gram-positive bacteria)) and antifungal (Candida albicans Aspergillus niger) studies.
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