期刊
RSC ADVANCES
卷 8, 期 19, 页码 10172-10178出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ra13674a
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资金
- Research Found of Karadeniz Technical University, Trabzon-Turkey
In this study a novel silicon(iv) phthalocyanine bearing [(2E)-3-[4-(dimethylamino)phenyl]-1-(4-phenoxy)prop-2-en-1-one] group and its quaternized derivative at their axial positions were synthesized for the first time. Axially disubstituted silicon(iv) phthalocyanines were also characterized by various spectroscopic techniques. The inhibition of two human cytosolic carbonic anhydrase (hCA, EC 4.2.1.1) isozymes I and II, with axially disubstituted silicon phthalocyanines and their quaternized derivatives were investigated by using the esterase assay, with 4-nitrophenyl acetate as substrate. Silicon phthalocyanines ZM-1-Si, ZM-5-Si, ZT-Si and their quaternized derivatives ZM-1-SiQ, ZM-5-SiQ, ZT-SiQ showed IC50 values in the range of 0.0178-0.1653 M for hCA I and of 0.0172-0.1212 M against hCA II, respectively. This study is the first example of carbonic anhydrase enzyme inhibition of phthalocyanines.
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