期刊
RSC ADVANCES
卷 8, 期 23, 页码 12635-12640出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra01236a
关键词
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资金
- National Natural Science Foundation of China [61361002, 21662046]
- Yunnan Province Department of Education Fund [2016ZZX217]
- Applied Basic Research Project of Yunnan [2017FD156]
A concise and efficient protocol for the regioselective synthesis of dual 1,4-dihydropyridines with several substituted patterns has been developed from a cascade cyclization of enaminones and aldehydes in different media (EtOH/CH3CN). The one-pot cascade reaction involves at least five reactive sites and generates multiple C-C and C-N bonds. The established protocol explores the chemistry of enaminones by employing their three reactive sites. The method has several advantages including mild conditions, operational simplicity, and high bond-forming efficiency. It may offer promise in a variety of biochemical applications.
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