期刊
NATURE REVIEWS IMMUNOLOGY
卷 12, 期 6, 页码 459-471出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3215
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资金
- US National Institute of Allergy and Infectious Diseases (NIAID) [R01 AI071080]
- Roche Organ Transplantation Research Foundation [979162997]
- NIAID [R01 AI072630]
Investigations over the past two decades are revealing complexities in the regulation of the innate immune response, and how this response, in turn, controls adaptive immunity. Microbial exposure, infections and tissue damage that accompany solid-organ transplantation result in the release of pathogen- and damage-associated molecular patterns, as well as pathogen- or allograft-derived antigens. Here, we review these triggers of innate and adaptive immunity, and discuss emerging paradigms of the many ways in which infections and tissue damage might directly or indirectly affect alloreactivity and the outcome of transplanted allografts.
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