期刊
JALA
卷 17, 期 3, 页码 169-185出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2211068211435302
关键词
liquid handling; life science; high throughput; automation
资金
- U.S. National Science Foundation [IIS-0712845]
- China Scholarship Council
- National High Technology Research and Development Program of China [2006AA040203]
Liquid handling plays a pivotal role in life science laboratories. In experiments such as gene sequencing, protein crystallization, antibody testing, and drug screening, liquid biosamples frequently must be transferred between containers of varying sizes and/or dispensed onto substrates of varying types. The sample volumes are usually small, at the micro-or nanoliter level, and the number of transferred samples can be huge when investigating large-scope combinatorial conditions. Under these conditions, liquid handling by hand is tedious, time-consuming, and impractical. Consequently, there is a strong demand for automated liquid-handling methods such as sensor-integrated robotic systems. In this article, we survey the current state of the art in automatic liquid handling, including technologies developed by both industry and research institutions. We focus on methods for dealing with small volumes at high throughput and point out challenges for future advancements.
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