期刊
NUTRIENTS
卷 10, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/nu10070926
关键词
Taraxacum officinale Wigg; glutamate; oxidative stress; Nrf2/HO
资金
- National Science Foundation for Distinguished Young Scholars of China [31500288]
- National Natural Science Foundation of China [81760779]
- Science and Technology Department of Sichuan Province Project [2016NFP0004]
- Program for Science Foundation of Chengdu University of Traditional Chinese Medicine [CGZH1707]
Oxidative stress-mediated neuron damage is considered an important contributor to the pathogenesis and development of neurodegenerative diseases. Taraxacum officinale has been reported to possess antioxidant activities. However, whether it can protect neurons against oxidative damage and the underlying molecular mechanisms have not been fully determined. In the present study, we examined the neuroprotective effects of ethanol extracts of this plant (ETOW) on glutamate-induced oxidative stress in HT22 cells. Both cell viability and reactive oxygen species (ROS) assays showed that ETOW effectively attenuated glutamate-induced cytotoxicity and ROS generation. Furthermore, our results revealed that ETOW increased the expression of heme oxygenase-1 (HO-1) and promoted the nuclear translocation of nuclear factor erythroid 2-related factor-2 (Nrf2). The inhibitory effects of ETOW on glutamate-stimulated cell toxicity and ROS production were partially reversed by tin protoporphyrin (SnPP), an HO activity inhibitor. Taken together, these results demonstrate that ETOW can protect HT22 cells against glutamate-induced oxidative damage by inducing the Nrf2/HO-1 pathways. Our study supports the idea that Taraxacum officinale Wigg. is a promising agent for preventing neurodegenerative diseases.
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