期刊
JALA
卷 17, 期 1, 页码 59-65出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2211068211426550
关键词
wound healing; collective cell migration
资金
- University of Arizona TRIF
- National Institutes of Health [1DP2OD007161-01]
- National Science Foundation [0855890]
- James S. McDonnell Foundation
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [0855890] Funding Source: National Science Foundation
Collective cell migration plays essential roles in a wide spectrum of biological processes, such as embryogenesis, tissue regeneration, and cancer metastasis. Numerous wound-healing assays based on mechanical, chemical, optical, and electrical approaches have been developed to create model wounds in cell monolayers to study the collective cell migration processes. These approaches can result in different microenvironments for cells to migrate and possess diverse assay characteristics in terms of simplicity, throughput, reproducibility, and multiplexability. In this review, we provide an overview of advances in wound-healing assays and discuss their advantages and limitations in studying collective cell migration.
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