期刊
MATERIALS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/ma11071123
关键词
conducting polymers; electroactive polymers; medical devices; drug delivery; anti-inflammatory; antibiotic
类别
资金
- Higher Education Commission of Pakistan for an International Research Support Initiative Program (IRSIP) scholarship
- Royal Society Newton International Fellowship
- Lancaster University Faculty of Science and Technology Summer Internship
- Lancaster University Faculty of Science and Technology Early Career Internal Grant
- Royal Society [RG160449]
- EPSRC [EP/R003823/1]
- EPSRC [EP/R003823/1] Funding Source: UKRI
The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10-30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.
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