期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 42, 期 7, 页码 1435-1445出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-011-1378-7
关键词
Autism; Maternal antibodies; Autoantibodies; Fetal brain
资金
- NIEHS NIH HHS [P01 ES011269, 1 P01 ES11269-01] Funding Source: Medline
Autism spectrum disorders (ASDs) affect approximately 1 in 110 children in the United States. This report profiles fetal-brain reactive autoantibodies of a large cohort of mothers of children with autism and controls, yielding significant associations between the presence of IgG reactivity to fetal brain proteins at 37 and 73 kDa and a childhood diagnosis of full autism (p = 0.0005), which also correlated with lower expressive language scores (p = 0.005). Additionally, we report on reactivity to proteins at 39 and 73 kDa, which correlated with the broader diagnosis of ASD (p = 0.0007) and increased irritability on the Aberrant Behavioral Checklist (p = 0.05). This study provides evidence of multiple patterns of reactivity to fetal brain proteins by maternal antibodies associated with ASD and specific childhood behavioral outcomes.
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