期刊
FOOD & FUNCTION
卷 9, 期 7, 页码 3718-3731出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8fo00685g
关键词
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资金
- 12th 5 Year Plan for Science and Technology Development [2012BAD33B05]
- State Key Laboratory of Food Science and Technology of Jiangnan University in China [SKLF-ZZB-201609]
- National Natural Science Foundation of China [31571841, 31700301]
- Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province
- Research and Innovation Project for Graduate Students Academic Degree of Colleges and Universities of Jiangsu Province [KYLX16_0821]
Methionine-restricted diets (MRD) show an integrated series of beneficial health effects, including improving insulin sensitivity, limiting fat deposition, and decreasing oxidative stress, and inflammation responses. We aimed to explore the systemic responses to a MRD in mice fed with a high fat (HFD) and clarify the possible mechanism. Mice were fed with a control diet (0.86% methionine + 4% fat, CON), HFD (0.86% methionine + 20% fat), or MRD (0.17% methionine + 20% fat) for 22 consecutive weeks. HFD-fed mice showed widespread systemic metabolic disorders and thyroid dysfunction. A MRD significantly increased energy expenditure (e.g. fatty acid oxidation, glycolysis, and tricarboxylic acid cycle metabolism), regulated protein homeostasis, improved gut microbiota functions, prevented thyroid dysfunction, increased plasma thyroxine and triiodothyronine levels, decreased plasma thyroid stimulating hormone levels, increased type 2 deiodinase (DIO2) activity, and up-regulated mRNA and protein expression levels of DIO2 and thyroid hormone receptor 1 in the skeletal muscle. These results suggest that a MRD can improve the metabolic disorders induced by a HFD, and especially regulate energy and protein homeostasis likely through improved thyroid function. Thus, reducing methionine intake (e.g. through a vegan diet) may improve metabolic health in animals and humans.
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